Gabapentinoids Are Associated with Hip Fracture Risk Description Hip fractures were 30% more common among older people who were taking gabapentinoids.
The Best Way to Do a Spontaneous Breathing Trial Description Two reports suggest that a daily trial, as opposed to several in a day, is better.
Do GLP-1 Agonists Prevent Some Alcohol Use Disorder Hospitalizations? Description In this observational study, GLP-1 receptor agonists were associated with lower risk for AUD hospitalization.
No Benefit to Early Initiation of Norepinephrine for Septic Shock Description A meta-analysis of 12 studies of early versus late initiation of norepinephrine demonstrated similar mortality and intensive care unit length of stay.
Gravity vs. Wall-Suction Drainage During Thoracentesis: Is One Safer Than the Other? Description Chest discomfort and complications did not differ between the two methods.
What Do “Silent” Mucus Plugs in COPD Patients Tell Us? Description Mucus plugs seen on chest CT in patients without evident symptoms were associated with more-severe disease.
High-Flow Nasal Cannula Is Not Inferior to Noninvasive Ventilation for Many Patients with Acute Respiratory Failure Description The data are relatively convincing for hypoxemic respiratory failure but are less so for COPD exacerbations with hypercarbia.
Intensive vs. Standard Blood Pressure Lowering in Patients with Diabetes Description In a randomized trial, lowering systolic BP to ≈120 mm Hg resulted in fewer strokes.
Is “As-Needed” Blood Pressure Medication Really Needed in Inpatients? Description Treating inpatients who had asymptomatic BP elevations was associated with risk for acute kidney injury, myocardial infarction, stroke, or death.
Guidelines for the Primary Prevention of Stroke Description This is the first major update to these guidelines since 2014.